![]() Simple dental or dermatological procedures may not require interruption to warfarin therapy. FFP should be added to Prothrombinex-HT as a source of factor VII when used for warfarin reversal. ![]() It contains factors II, IX and X, and low levels of factor VII. Prothrombinex-HT is the only PCC approved in Australia and New Zealand for warfarin reversal. To temporarily reverse the effect of warfarin when there is a need to continue warfarin therapy, vitamin K 1 should be given in a dose that will quickly lower the INR to a safe, but not subtherapeutic, range and will not cause resistance once warfarin is reinstated. When oral vitamin K 1 is used for warfarin reversal, the injectable formulation of vitamin K 1 is preferable to tablets because of its flexible dosing this formulation can be given orally or injected. Vitamin K 1 is essential for sustaining the reversal achieved by PCC and FFP. Immediate reversal is achieved with a prothrombin complex concentrate (PCC) and fresh frozen plasma (FFP). To reverse the effects of warfarin, vitamin K 1 can be given. Risk factors for bleeding complications with warfarin use include age, history of past bleeding and specific comorbid conditions. ![]() ![]() Statistics, epidemiology and research designįor most warfarin indications, the target maintenance international normalised ratio (INR) is 2–3. ![]()
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